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In this slideshow, we feature a review by Italian rheumatologists who compare subcutaneous and oral methotrexate outcomes in rheumatoid arthritis patients.

Photo courtesy of Hitomi Kobayshi, M.D., Ph.D.

Heart disease in rheumatoid arthritis is well known, but whether it's present in RA patients with no known heart disease or risk factors is not as well known.

(Anatomy of Human Heart ©LiyaGraphics/Shutterstock.com)

Myocardial inflammation/fibrosis has been identified in a study of rheumatoid arthritis patients with no known history of heart disease.

(Post-op knee replacement ©GoneWithTheWind/Shutterstock.com)

Pre-surgical widespread body pain is associated with persistent pain in patients following total knee arthroplasty at 12 months post-surgery, researchers report.

(Blisters ©komkritPreechachanwat/Shutterstock.com)

Researchers have made an important discovery that may lead to new treatment for patients with bullous pemphigoid, a chronic autoimmune skin disease causing blisters.

(Strenth training @AdamGregor/Shutterstock.com)

The elderly can build lower limb bone strength with habitual weight-bearing exercises, not medium or low impact exercise, research shows.

In this news roundup, we offer a snapshot of some interesting studies we featured that pose never-ending perplexing questions: When do I switch patients from methotrexate to a biologic? Why didn't my patient report having an adverse reaction? Does vitamin D really protect bones?

(Side effects ©CatherineLall/Shutterstock.com)

Some biologics produce hypersensitivity reactions more than others, but for most, the events are low, researchers report.

Subcutaneous fluid (©AnnaJurkovska/Shutterstock.com)

Methotrexate is "dramatically" underutilized, prescribed at suboptimal levels, prescribed for too short of periods and is not administered correctly, researchers report.

(Child and adult hands ©PuwadolJaturawutthichai/ShutterStock.com)

Researchers writing in Annals of the Rheumatic Diseases say they have identified a link between juvenile idiopathic arthritis and adult rheumatoid arthritis.

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