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Early Lupus Features, Early Diagnosis: Page 2 of 2

Early Lupus Features, Early Diagnosis: Page 2 of 2

The following early clinical features occurred most often in systemic lupus erythematosus cases: arthritis or arthralgia, rash, fatigue, headache, and depression.

The best fitting risk prediction model included the following variables: age, sex, consultation rate, arthralgia or arthritis, rash, alopecia, sicca, Raynaud phenomenon, serositis, and fatigue. This model might be used in the future to help primary care providers identify patients who have systemic lupus erythematosus.

“Early clinical features may be mild and common, but presentation with 2 or more features should prompt clinical review and consideration of investigation such as with ANA,” wrote Rees and colleagues. “A risk prediction model has been developed and validated, which may assist this decision-making process in the future following further evaluation.”



This research was supported by Lupus UK.

Professor Doherty has received advisory board honoraria from AstraZeneca, Nordic Biosciences, and Novartis (less than $10,000 each). Dr. Lanyon has received advisory board honoraria from Lilly and speaking fees from Pfizer (less than $10,000 each). Dr. Davenport has received advisory board honoraria from AstraZeneca and Consilient Health (less than $10,000 each).


Rees, F., Doherty, M., Lanyon, P., et al. “Early Clinical Features in Systemic Lupus Erythematosus: Can They Be Used to Achieve Earlier Diagnosis? A Risk Prediction Model.” Arthritis Care & Research. Published online May 8, 2017. DOI: 10.1002/acr.23021

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