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Eliglustat has a better safety profile than the existing approved oral drug for type 1 Gaucher disease, and is easier to take than enzyme replacement therapy.

A new international multicenter study of often-deadly macrophage activation syndrome in systemic JIA reveals key laboratory and clinical warning signs. Watch ferritin levels especially closely.

For psoriasis patients, dermatologists are told, liver biopsy results may be misleading after methotrexate treatment. Noninvasive methods of assessment are no worse, but need improving and standardizing.

A new auto-injectable form of methotrexate offers 10 dosage options. Is this an important advantage for medication management and adherence over the four already available?

Adalimumab (Humira) may alter production of tumor necrosis factor-alpha in rheumatoid arthritis patients, returning TNFα levels almost to normal. A study looking at antibodies against the drug in psoriatic arthritis found no clear evidence of an effect.

An IL4 fusion protein has completely resolved rheumatoid arthritis in a mouse study using a standard collagen-induced model of the disease.

Knee osteoarthritis can trigger a series of clinical problems that set patients on the road to early frailty, especially if both knees are involved. It's prudent for their physicians to be on high alert for it.

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