For psoriasis patients, dermatologists are told, liver biopsy results may be misleading after methotrexate treatment. Noninvasive methods of assessment are no worse, but need improving and standardizing.
Adalimumab (Humira) may alter production of tumor necrosis factor-alpha in rheumatoid arthritis patients, returning TNFα levels almost to normal. A study looking at antibodies against the drug in psoriatic arthritis found no clear evidence of an effect.
Knee osteoarthritis can trigger a series of clinical problems that set patients on the road to early frailty, especially if both knees are involved. It's prudent for their physicians to be on high alert for it.