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Osteoarthritis

Can the "Formulary Police" Be Stopped?

Demands for prior approvals (PAs) have begun to spread, virus-like, from top-dollar biologics to familiar standards such as methotrexate. A quick survey by an Alabama rheumatologist reveals the additional high cost to practices of merely dealing with all those PAs. And who's practicing rheumatology now -- you or those health-plan clerks? What can be done? He offers a solution ...

Osteoarthritis

(AAOS2015) Evidence from large insurance databases shows that knee replacement often quickly follows arthroscopy or injections. It would make (economic and clinical) sense to go straight to surgery, the researchers contend.

(AAOS2015) Total knee replacements appear successful for the relatively young and active as well as for those over 90. For people with the most preoperative pain, however, they may not help at all.

(AAOS2015) The first study to assess the effect of steroid injections on the hip joint suggests that they may hasten joint degeneration, but the co-injected local anesthetic is also suspect.

Pfizer and Lilly will resume development of the anti-nerve growth factor monoclonal antibody tanezumab for osteoarthritis pain, after the FDA lifted its ban imposed due to adverse effects in animal trials.

The good news: At best, intraarticular hyaluronate injected into the knee for osteoarthritis (OA) is modestly effective. The bad news: At worst, it’s indistinguishable from placebo, in some meta-analyses.

knee osteoarthritis

An article describes attractive reasons to defer knee replacement. Researchers are working to find ways to replace damaged cartilage and collagen, and promote healing within the joint.

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