In the second installment of a slide show based on an animated discussion by members of the rheumatology journal club (#rheumjc), partipants focus on the benefits, risks, and realities of tapering biologics in clinical practice.
Slides present key points from a Twitter-based journal club, pondering a randomized study of tapering TNF inhibitors in rheumatoid arthritis. Many questions about the study design. More ask about practices already in use (addressed in Part 2).
Studies on banked cells from humans in different regions of the world reveal that many genes that control immune function behave differently in winter and summer. They are more pro-inflammatory in the winter.
(OARSI2015) Osteoarthritis specialists hope researchers will help them unite individual patient data from different trials to conquer difficult questions about the disease.
(OARSI2015) Researchers can now describe how osteoarthritis patients may become sensitized to feel pain beyond the affected joint. Different brain areas are triggered than in fibromyalgia, and biochemical studies offer clues to new kinds of pain relief.
(OARSI2015) A new systematic review found intra-articular hyaluronic acid mildly effective for knee osteoarthritis pain, despite significant weaknesses and risks of bias in the trials. Another study using a large database found that the injections delay knee replacement.
(OARSI2015) First results are now in for a large collaborative project whose goal is to rationalize OA research by finding the best imaging and biochemical measures of progression.
(OARSI2015) Musculoskeletal signs predict which patients will do poorly after joint replacement surgery, but the Medicare agency does not include these in rating hospitals. The information could also be useful for surgeons and patients, says this investigator.
(OARSI2015) A randomized trial has shown that 6 months of treatment with hydroxychloroquine does not provide better relief for hand osteoarthritis than placebo.
(OARSI2015) What advice about exercise is prudent for your patients with knee osteoarthritis? Speakers in Seattle offered a few simple suggestions, based on the latest research.