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Author | Rediet Kokebie, MD


Managing osteoarthritis: Current and future directions

ABSTRACT: Osteoarthritis (OA) was considered a disease of articularcartilage but now is thought to involve the entire joint. Research findingshave helped improve the understanding of disease progressionand the strategies used to alter the disease course. There is no laboratoryor pathological definition of OA; the diagnosis must be madeclinically. The approach to treatment should be tailored to specific patients.Topical agents often are used before oral medications. NSAIDsand cyclooxygenase-2 inhibitors remain the mainstay of therapy.Intra-articular corticosteroid injections have been shown to provideshort-term relief, and several hyaluronans are available for use inknee OA. Surgery may be required; modern implants provide significantpain relief and have proved to be durable and functional.(J Musculoskel Med. 2008;25:346-352)