Musculoskeletal Citations

 

Guselkumab vs Adalimumab in Plaque Psoriasis

July 22, 2015

Guselkumab, a selective antagonist of IL-23, went head to head with adalimumab in a year-long phase 2 trial of 293 patients with moderate to severe plaque psoriasis. A quick synopsis of the results here.

Anakinra in Pyoderma Gangrenosum

July 22, 2015

A case report describes the use of anakinra in a patient with psoriatic arthritis in whom pyoderma gangrenosum developed. The ulcer had not responded to any other therapies.

Breathless with Rheumatoid Arthritis: A Case of ILD

July 20, 2015

This is a case report of a patient with rheumatoid arthritis in whom interstitial lung disease (ILD) developed. ILD is one of several pulmonary complications of RA.

The Case of Shingles-Induced Koebner Phenomenon in a Man with Psoriasis

July 17, 2015

Here is the case of a 30-year-old man with scalp psoriasis in whom Koebner phenomenon developed at areas of developing shingles.

Osteoporosis Rx Update: Sequential and Combination Therapy

July 07, 2015

New study results shed light on questions about the effect of combining drugs to treat osteoporosis and what happens after a switch from one drug to another.

First-Line Rx in Pyoderma Gangrenosum

July 02, 2015

There is now clinical evidence to support cyclosporine and prednisolone as first line options in the treatment of pyoderma gangrenosum.

Ischemic Optic Neuropathy--Feared Complication of Giant Cell Arteritis

June 30, 2015

A review of ischemic optic neuropathies--arteritic and nonarteritic.

Viscosupplementation for OA of the Knee?

June 29, 2015

NEJM weighs weak evidence of benefit against small risk of viscosupplementation for osteoarthritic knees and recommends against it.

Add Rituximab to Methotrexate in RA?

June 26, 2015

Adding rituximab to methotrexate improved outcomes in rheumatoid arthritis, without increasing adverse effects. There were some caveats, however.

Thumbs Down on Arthroscopic Knee Surgery

June 26, 2015

This systemic review and meta-analysis found no significant benefit to arthroscopic knee surgery. An editorialist asks, “In light of this evidence, why is arthroscopy still so common?”