Musculoskeletal Citations

 

Guselkumab vs Adalimumab in Plaque Psoriasis

July 22, 2015

Guselkumab, a selective antagonist of IL-23, went head to head with adalimumab in a year-long phase 2 trial of 293 patients with moderate to severe plaque psoriasis. A quick synopsis of the results here.

Anakinra in Pyoderma Gangrenosum

July 22, 2015

A case report describes the use of anakinra in a patient with psoriatic arthritis in whom pyoderma gangrenosum developed. The ulcer had not responded to any other therapies.

Breathless with Rheumatoid Arthritis: A Case of ILD

July 20, 2015

This is a case report of a patient with rheumatoid arthritis in whom interstitial lung disease (ILD) developed. ILD is one of several pulmonary complications of RA.

The Case of Shingles-Induced Koebner Phenomenon in a Man with Psoriasis

July 17, 2015

Here is the case of a 30-year-old man with scalp psoriasis in whom Koebner phenomenon developed at areas of developing shingles.

Osteoporosis Rx Update: Sequential and Combination Therapy

July 07, 2015

New study results shed light on questions about the effect of combining drugs to treat osteoporosis and what happens after a switch from one drug to another.

First-Line Rx in Pyoderma Gangrenosum

July 02, 2015

There is now clinical evidence to support cyclosporine and prednisolone as first line options in the treatment of pyoderma gangrenosum.

Ischemic Optic Neuropathy--Feared Complication of Giant Cell Arteritis

June 30, 2015

A review of ischemic optic neuropathies--arteritic and nonarteritic.

Viscosupplementation for OA of the Knee?

June 29, 2015

NEJM weighs weak evidence of benefit against small risk of viscosupplementation for osteoarthritic knees and recommends against it.

Add Rituximab to Methotrexate in RA?

June 26, 2015

Adding rituximab to methotrexate improved outcomes in rheumatoid arthritis, without increasing adverse effects. There were some caveats, however.

Thumbs Down on Arthroscopic Knee Surgery

June 26, 2015

This systemic review and meta-analysis found no significant benefit to arthroscopic knee surgery. An editorialist asks, “In light of this evidence, why is arthroscopy still so common?”

Chronic Fatigue Syndrome: A Review of the Evidence

June 22, 2015

Difficult diagnosis, overlap with other conditions, lack of objective signs, the absence of proven treatment. . . these reviews of chronic fatigue syndrome filter and summarize the most rigorous evidence available.

Drugs for Psoriatic Arthritis--and Their Cost

June 22, 2015

This overview of NSAIDs, corticosteroids, DMRDs, PDE4 inhibitors, and biologic agents offers recommendations for first-line options for mild and moderate-to-severe psoriatic arthritis.

Tofacitinib in Chronic Plaque Psoriasis

June 17, 2015

In a 12-week phase 3 trial, tofacitinib,10 mg twice a day, was non-inferior to etanercept, 50 mg twice a week. Tofacitinib, 5 mg twice a day, was inferior to etanercept.

Your History of Viral Exposure Revealed

June 16, 2015

The VirScan system can measure a subject's exposure to all known human viruses. This will enable population studies that find any associations with a particular viral infection for every rheumatological disease. And it only costs about $25 per blood sample.

Spondylitis and Aortic Regurgitation

June 12, 2015

Many patients with ankylosing spondylitis have aortic regurgitation: this study makes the case for routine echocardiography evaluation.

NEJM Makes Myositis as Clear as Possible

June 11, 2015

A comprehensive review has compiled and summarized all current information about pathology, diagnosis, and treatment of the various subsets of myositis.

Dental Issues (Not Opening Wide ... ) a Severity Indicator in SSc

June 05, 2015

Hardening of the skin in systemic sclerosis impairs patients' ability to care for their own teeth properly. As a result, this study suggests, dental issues may be prognostic indicators.

Ten Diagnostic Signs of ILD, and More

May 28, 2015

Key features in the clinical examination of interstitial lung diseases and their management are the focus of a new clinical review. Highlights here.

Study Finds Ethnic Pattern in Infliximab Antibody Risk

May 22, 2015

One very targeted clue to treatment failure: An observational study from Israel identifies Sephardic Jews as more likely than Ashkenazim to form antibodies against the biologic drug infliximab.

Adalimumab Safe and Effective for Non-Psoriatic SpA

May 20, 2015

The biologic adalimumab improves pain and physical function in a randomized trial of patients with peripheral spondyloarthritis unable to take non-steroidal anti-inflammatory drugs.