The Rheumatology Network osteoarthritis clinical focus page provides information on the latest osteoarthritis and osteoporosis news, study and clinical trial findings, and clinical guideline updates. We feature expert interviews with leading physicians and investigators, articles, videos, podcasts, and breaking FDA approvals for osteoarthritis drugs.

Combatting Sedentary Behavior in Patients With Knee Osteoarthritis or Replacement

February 09, 2021

Investigators set out to explore sedentary behavior, physical and mental limitations, the willingness of this patient population to engage in more regular exercise, how perceptive they were to using technology to support a more active lifestyle, and interventions to reduce sedentary time.

Exercise Types Essential in Rheumatic Disease

October 31, 2020

Patients with inflammatory arthritis and osteoarthritis should be participating in four different types of exercise: cardiovascular, strength, flexibility, and balance. But a new study shows that patients are overly focused on cardiovascular exercise and not enough on exercise types designed to strengthen and protect joints and bones. In this interview, Dr. Lauren Freid, a rheumatologist with the University of California Los Angeles and the lead investigator of a study on physical activity in people with inflammatory arthritis and osteoarthritis, addresses exercise essentials for inflammatory rheumatic disease.

Anxiety Sets in Two Years After Knee Replacement

October 31, 2020

Psychosocial factors, such as support, depression, coping, and optimism are associated with pain, function, and satisfaction two years after total knee arthroplasty, shows a study from MD Anderson Cancer Center.

Total Joint Surgery May Lower Fall Risk

October 22, 2020

A new study published in the Journal of the American Academy of Orthopaedic Surgeons shows that patients with advanced osteoarthritis who undergo total joint replacement, significantly lower their risk of falls after surgery as compared to patients who opt out of surgery.

An Osteoarthritis Diagnosis of the Future May Be Driven by AI

October 14, 2020

Researchers have created a machine-learning algorithm that can detect subtle signs of osteoarthritis—too abstract to register in the eye of a trained radiologist—on an MRI scan taken years before symptoms even begin.

Bisphosphonate Use Associated with Increased Fracture Risk

September 16, 2020

Bisphosphonate use, especially for more than five years, is associated with an increased risk of atypical femoral fractures, but this risk falls considerably after discontinuation, according to a Nationwide Danish an analysis and review presented on September 13 at the American Society for Bone and Mineral Research (ASBMR) annual meeting which was held virtually.

Teriparatide for Bone Formation in Hip Fractures

September 16, 2020

Teriparatide, a recombinant human parathyroid hormone analog [rhPTH(1-34)] approved for women and men with osteoporosis, has been shown to renew bone tissue in patients with femoral neck fractures of the hip, according to research presented at the American Society for Bone and Mineral Research (ASBMR) annual meeting which was held this week.

Vitamin D and Fish Oil Fail Osteoarthritis Trial

June 25, 2020

New research published in Arthritis and Rheumatology shows that vitamin D and marine omega‐3 fatty acids (n‐3 FA) do not offer long-term relief from knee pain, stiffness or function in older adults with chronic knee pain.

Study Shows Footwear Relieves Osteoarthritic Knee Pain

May 27, 2020

A new study shows that biomechanical footwear improved osteoarthritis knee pain at 24 weeks as compared to patients in a control group who wore traditional footwear. The results, although statistically significant, need to be replicated to prove clinical importance, researchers reported in JAMA.

Osteoarthritis Risk Intensifies With Epigenetics

May 13, 2020

The risk for osteoarthritis has been linked to a number of genes that are susceptible to epigenetic mediators, shows a new review published in Nature Reviews Rheumatology. The influence of epigenetics on osteoarthritis offers new insights on disease risk.

Are glucocorticoid injections still necessary for osteoarthritis knee pain?

May 12, 2020

In patients with knee osteoarthritis, physical therapy may improve pain and functional disability more so than intraarticular glucocorticoid injections, at one year, according to a head-to-head study published in the New England Journal of Medicine.

Fast Facts on Vitamin D, Calcium and Fracture

February 07, 2020

In this slideshow we highlight some key facts about the use of supplements to prevent fracture in women and men over the age of 50. Existing treatment guildelines recommend a combination approach with vitamin D and calcium, but some clinical trials are not entirely in agreement. Learn more in this slideshow.

Motion Tests Essential for an Osteoarthritis Diagnosis

January 28, 2020

Simple hip motion tests and observing for pain during that motion were helpful in identifying patients most likely to have hip osteoarthritis on plain radiography, say researchers recently writing in the Journal of the American Medical Association.

Drug and Nondrug Approaches for Treating Osteoarthritis

January 10, 2020

Updated treatment guidelines for hand, hip and knee osteoarthritis have been issued. In this slideshow, we highlight recommendations for the use (or not) of drug and nondrug treatments. These include strong recommendations for standard treatment options, such as weight loss and Tai Chi, and strong recommendations against treatments with pharmacologicals, such as glucosamine and chondroitin sulfate (except for hand osteoarthritis). Learn more in this slideshow.

Sprifermin Improves Cartilage Thickness, but Clinical Benefit Uncertain

December 12, 2019

Intra-articular administration of sprifermin statistically increases total femorotibial joint cartilage thickness in individuals with symptomatic radiographic knee osteoarthritis, but the clinical importance and duration of the effect are uncertain, say researchers writing recently in JAMA.