Rheumatology

The selective, allosteric tyrosine kinase 2 inhibitor demonstrated significant and clinically meaningful improvements in PROs versus placebo in a phase 2 trial of patients with PsA.

A meta-analysis found febuxostat was linked to a greater risk for acute coronary syndrome and atrial fibrillation than allopurinol among Asian patients with and without gout.

Psoriatic arthritis and spondyloarthritis occurred earlier in children and adolescents with IBD than in the matched references without IBD.

Between 2009 and 2020, the number of rheumatologists increased 23%, from 4557 to 5600.

Participants with an RA risk had various opinions on preventive measures, from being on board, needing to be swayed by a doctor, and fearing the intervention.

The analysis of NHANES 2005-2016 data found exposure to thiocyanate, either alone or in combination with perchlorate and nitrate, was associated with arthritis vulnerability and inflammation.

A new study found RA patients with concomitant Sjögren’s disease were more likely to fail TNFi treatment than the treatments of other mode of action biologics and JAKi.

Results showed co-administration of methotrexate with pegloticase led to similar rates of urate-lowering response and adverse events in patients with and without CKD.

A 6-week bodyweight exercise program led to improved muscle strength, range of motion, and physical fitness test results in female patients with RA.

A new study suggests patients with either rheumatoid arthritis or osteoarthritis may be at a higher genetic susceptibility to develop COPD.

A comparison of the urate-lowering therapies shows discrepancies in short- and long-term use outcomes.

A new study evaluated gender differences in physical functioning, sexual dysfunction, depression, fatigue, pain, and loneliness among RA patients using and not using methotrexate.

Findings suggest a positive association between valine, leucine, and isoleucine intake with RA risk, although total and individual dietary BCAA intake were not related to disease activity parameters.

Of 1156 participants with chronic musculoskeletal pain, 1073 participants retired at an earlier age. Participants with chronic pain were 1.25 times more likely to stop working.

Participants with RA had a 1.66-fold greater risk of depression compared to participants without RA, a new study found.

After propensity score matching, patients with COVID-19 were at an increased risk for AIRD when compared with both uninfected controls and influenza-infected patients.

This article serves as a landing page for our 3-part series spotlighting how a lack of diversity in clinical trials has had a deleterious downstream effect on real-world care for people of color in the US, with perspective from experts across more than half a dozen specialties.

In an analysis of the DISCOVER-2 trial, guselkumab treatment reduced impairment in work productivity and improved general health status in PsA over 2 years.

Headache prevalence was significantly higher in the PsA and axSpA cohorts compared with healthy controls.

The presence of sinusitis is linked to a 40% heightened risk of a diagnosis of rheumatic disease, particularly in the 5 to 10 years before disease onset.

Most patients (82.6%) had minimal psoriasis skin involvement with a body surface area of < 3. However, 15.1% and 2.4% had a body surface area involvement of 3 – 10% and > 10, respectively.

Patients with gout and negative DECTs for monosodium urate crystal deposition exhibited milder disease and a lower comorbidity burden.

Interactions with alcohol consumption were identified at ADH1B and MLXIPL for association with serum urate level and at ADH1B for association with hyperuricemia and gout

Urate-lowering therapy and dosing regimen impact the risk of gout flares, with greater fixed dosing linked to a greater risk of flares and prophylaxis associated with reductions in flare risk.

A groundbreaking phase 1 study using CAR-T cells to treat severe lupus highlights a collaborative effort between the Cellular Therapy Program and rheumatology programs to pioneer innovative patient care.

The study performed the first genome-wide cross-trait analysis to investigate the shared genetic basis underlying hypothyroidism and rheumatoid arthritis.

Anisha Dua, MD, MPH, sheds light on the intricate challenges posed by vasculitis and its mimics.

A Mendelian randomization analysis provided new insights into the relationship between inflammatory cytokines and ankylosing spondylitis, rheumatoid arthritis, and psoriatic arthritis.

A Finnish study finds elevated cardiovascular risk in rheumatic diseases peaks within a year of diagnosis, emphasizing the need for early management strategies.

Patients with ACPA-positive RA and obesity had greater DAS44 scores compared to normal-weight patients, although this difference was not present in ACPA-negative RA.