New research has examined 3D motion and muscle activity in knee osteoarthritis, and correlated gait with pain. Result: a better description of knees destined for replacement.
Synovitis is present in 90% of painful knees, and emerging data is showing that this inflammation is "not just a bystander" in osteoarthritis-induced damage. Research is revealing the roles of macrophages and T-cells, and signposts toward new drug targets.
No speaker at the OARSI meeting turned up with the Holy Grail -- a new disease modifying osteoarthritis drug (DMOAD). Some promising alternatives are not available to US patients; others are in very preliminary testing.
Patients with knee osteoarthritis should have mild exercise every day to reduce inflammation, should walk with shorter steps to reduce knee loading, and should strengthen their upper leg muscles, to judge from new research. But studies have yet to say how much exercise is best, how often, and at what intensity.
What you want to see in progressive images of knee osteoarthritis is not a particular kind of change, but homeostasis, to judge from two studies presented at the annual meeting of OARSI.
At the OARSI annual meeting in Philadelphia, two osteoarthritis experts tacklde the issue of whether to focus first on structural abnormalities or pain, and merged toward a consensus.
A set of six simple performance-based measures have been recommended by the Osteoarthritis Research Society International for assessing physical function in osteoarthritis of the knee and hip.
OARSI 2013: More support for the supplement chondroitin sulfate (CS) in osteoarthritis: In a large observational study from Spain, six months' use of CS significantly reduced the likelihood of having total knee replacement. Observers noted the well-known issues in applying this knowledge in the US.