It’s not just weight that could be contributing to degenerative changes in obesity-related osteoarthritis. In this Q&A, Dr. Clifford J. Rosen, director of the Center for Clinical and Translational Research, Maine Medical Center Research Institute, Portland, discusses the mechanisms of osteoarthritis.
Three studies presented this weekend at EULAR in Madrid suggest that being overweight or obese can heighten the severity or arthritic disease.
Obese patients with osteoarthritis who take metformin have a slower rate of medial cartilage loss, putting them at a reduced risk for total knee replacement, a new study found.
An inexpensive and relatively benign supplement may reduce OA inflammation.
Does the obesity paradox suggest a protective effect?
Swedish researchers found a 30% increase in the risk of fractures—independent of the degree of weight loss.
Identifying populations at risk may provide opportunities for primary prevention.
Both weight loss and obesity are associated with worsening disability in RA.
Patients experience higher disease activity, lower quality of life, and worse physical functioning.
Associated comorbidities can bias clinical disease activity measures.