Following garlic supplementation for 12 weeks, serum concentrations of resistin were significantly decreased in the garlic group (6.41 ± 2.40 to 5.56 ± 2.16 ng/mL; P = .008). No significant changes in TNF-α concentration were observed within or between the garlic and placebo groups.
Pain scores were significantly decreased in the garlic group (6.8 ± 2 to 5.3 ± 2.3; P = .002) but not in the placebo group (6.7 ± 2.4 to 6.2 ± 2.5; P = .674). Pain scores were also significantly lower in the garlic group than in the placebo group at week 12 (5.3 ± 2.3 vs 6.2 ± 2.5; P = .043).
• Clinicians may counsel overweight and obese women with OA that supplementation with garlic may help reduce knee pain.
• Garlic is an inexpensive and relatively benign supplement that may reduce OA inflammation.
• While resistin levels were reduced in the garlic group, TNF-α levels were not.
• Pain relief in knee osteoarthritis may be mediated by the reduction in resistin in obese women.
• Overweight and obese women with knee OA can be encouraged that the use of garlic in their daily diets may improve joint pain with little downside.
Next: final thoughts.
1. Dehghani S, Alipoor E, Salimzadeh A, et al. The effect of a garlic supplement on the pro-inflammatory adipocytokines, resistin and tumor necrosis factor-alpha, and on pain severity, in overweight or obese women with knee osteoarthritis. Phytomedicine. 2018;48:70-75. doi: 10.1016/j.phymed.2018.04.060.