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A Case of Dermatomyositis-Associated Calcinosis

Hard, mobile, painless subcutaneous nodules developed in this woman who had had dermatomyositis for 20 years. The calcifications progressed during treatment with infliximab.

Siddiqui NS, Altorok N. Images in Clinical Medicine: Diffuse Soft-Tissue Calcinosis. N Engl J Med. 2015; 373:173. July 9, 2015. DOI: 10.1056/NEJMicm1407238


A 50-year-old woman had been diagnosed with dermatomyositis 20 years earlier.

Treatment with methotrexate and prednisone resulted in remission of myopathy, but the patient continued to have an inflammatory skin disease.

For the last 10 years, she had progression of hard, mobile, painless subcutaneous nodules.

The presentation was consistent with dermatomyositis-associated calcinosis, which can also be seen in disorders such as systemic sclerosis (scleroderma).

The calcifications progressed during treatment with infliximab.