A longitudinal study of adults with childhood-onset lupus shows that disease damage accrues over the entire disease course.
A longitudinal study of adults with childhood-onset systemic lupus erythematosus shows that disease damage accrues over the entire disease course for these patients without plateauing, researchers recently reported in Arthritis Care and Research.
The study, conducted by Earl Silverman, M.D., and colleagues of Toronto SickKids Hospital, included 473 patients with an average age of 22.2 years. The patients were followed for an average of 5.63 years (or, a maximum of 26.3 years).
Prior to this study, only four other studies had been conducted examining the outcomes of childhood-onset systemic lupus erythematosus patients. This study is important because it identifies prognostic factors that physicians should consider in managing care in a way that modifies the trajectory of damage over a patient’s life.
Here is a summary of the most poignant points from the study:
Lily SH Lim, Eleanor Pullenayegum, Lillian Lim, Dafna Gladman, Brian Feldman, Earl Silverman. "From Childhood to Adulthood: The Trajectory of Damage in Patients with Childhood-Onset Systemic Lupus Erythematosus," Jan. 24, 2017. Arthritis Care and Research. DOI: 10.1002/acr.23199