NSAIDs: How Safe for High-Risk Patients?

Dec 19, 2018

Canadian researchers looked at the safety of short-term use in patients with hypertension, heart failure, or chronic kidney disease.

Bouck and colleagues in Canada discovered that nonsteroidal anti-inflammatory drugs (NSAIDs) are widely prescribed to patients considered to be at high risk for NSAID-related complications, such as those with hypertension, heart failure, or chronic kidney disease. However, the investigators found no increase in short-term safety-related outcomes.¹ Scroll through the slides for the details of their study and the take-home points for clinicians.

NSAID, nonsteroidal anti-inflammatory drug.

Complications of NSAID use include hypertension, edema, impaired renal function, and myocardial infarction.

CKD, chronic kidney disease; NSAID, nonsteroidal anti-inflammatory drug.

NSAID, nonsteroidal anti-inflammatory drug.

CKD, chronic kidney disease; NSAID, nonsteroidal anti-inflammatory drug.

NSAID, nonsteroidal anti-inflammatory drug.

Reference

1. Bouck Z, Mecredy GC, Ivers NM, et al. Frequency and associations of prescription nonsteroidal anti-inflammatory drug use among patients with a musculoskeletal disorder and hypertension, heart failure, or chronic kidney disease. JAMA Intern Med. 2018;178:1516-1525. doi: 10.1001/jamainternmed.2018.4273.