T Cells Implicated in Regulation of RA Disease Activity in Men but Not Women

Aug 29, 2018

What underlies the apparent disparities in disease course and treatment outcomes between men and women with rheumatoid arthritis?

Reference1. Aldridge J, Pandya JM, Meurs L, et al. Sex-based differences in association between circulating T cell subsets and disease activity in untreated early rheumatoid arthritis patients. Arthritis Res Ther. 2018;20:150. doi: 10.1186/s13075-018-1648-2.

Aldridge and fellow researchers in Sweden found that there are sex-based differences in the association between T cell subsets and disease activity in rheumatoid arthritis (RA). T cells were implicated only in men with RA.¹ Scroll through the slides for the details of the study and the take-home points for physicians.

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RA, rheumatoid arthritis.

CDAI, Clinical Disease Activity Index; CRP, C-reactive protein; DAS28, disease activity score in 28 joints; ESR, erythrocyte sedimentation rate; RA, rheumatoid arthritis.

ueRA, untreated early rheumatoid arthritis.