Osteoarthritis

 

The Rheumatology Network osteoarthritis clinical focus page provides information on the latest osteoarthritis and osteoporosis news, study and clinical trial findings, and clinical guideline updates. We feature expert interviews with leading physicians and investigators, articles, videos, podcasts, and breaking FDA approvals for osteoarthritis drugs.

Philip Conaghan, MBBS, PhD: Efficacy of Tanezumab in Patients With Osteoarthritis

September 08, 2021

Philip Conaghan, MBBS, PhD, discusses his presentation entitled, “Meaningful Improvements in WOMAC Pain and Physical Function in 3 Phase 3 Trials of Tanezumab in Patients With Moderate-to-Severe Osteoarthritis: A Responder Analysis.”

Activity Monitor Usage in Patients Requiring Total Knee Replacements

September 08, 2021

Despite the benefits of physical activity, participation is low, both within the general population and among individuals with osteoarthritis (OA). Activity monitors may aid in increasing these levels in patients with OA as well as in those requiring a total knee replacement.

Q&A: Clinical, Molecular Associations With Knee Injury Outcomes

July 12, 2021

In this Q&A, corresponding author, Fiona Watt, MBBS, PhD, FRCP, discusses her study that found the combination of effusion and hemarthrosis at the time of acute knee injury is associated with adverse outcomes at 2 years post-injury.

Gene Therapy Improves Pain Management and Disease Progression for Osteoarthritis

June 24, 2021

Treatment of the osteoarthritis has been at a standstill, with short-term pain management with steroid injections considered standard care. However, a promising new therapeutic approach may help to sustain pain relief over time.

Nicholas Brisson, PhD: Machine Learning Equation Provides Predictions for Knee Osteoarthritis Outcomes

May 24, 2021

Rheumatology Network interviewed Nicholas Brisson, PhD, to discuss his recent study, “Association of machine learning based predictions of medial knee contact force with cartilage loss over 2.5 years in knee osteoarthritis." The study discovered that machine learning was able to develop an equation for predicting medial tibiofemoral contact force (MCF) peak, which supports the theory that mechanical loading directly contributes to disease progression.

Women With PCOS May be at a Greater Risk of Developing Osteoarthritis

May 07, 2021

Women with polycystic ovary syndrome (PCOS) are more likely to suffer from knee-related symptoms and impaired activities of daily living, indicating a possible link between hyperandrogenism and early clinical osteoarthritis.

Combatting Sedentary Behavior in Patients With Knee Osteoarthritis or Replacement

February 09, 2021

Investigators set out to explore sedentary behavior, physical and mental limitations, the willingness of this patient population to engage in more regular exercise, how perceptive they were to using technology to support a more active lifestyle, and interventions to reduce sedentary time.

Exercise Types Essential in Rheumatic Disease

October 31, 2020

Patients with inflammatory arthritis and osteoarthritis should be participating in four different types of exercise: cardiovascular, strength, flexibility, and balance. But a new study shows that patients are overly focused on cardiovascular exercise and not enough on exercise types designed to strengthen and protect joints and bones. In this interview, Dr. Lauren Freid, a rheumatologist with the University of California Los Angeles and the lead investigator of a study on physical activity in people with inflammatory arthritis and osteoarthritis, addresses exercise essentials for inflammatory rheumatic disease.

Anxiety Sets in Two Years After Knee Replacement

October 31, 2020

Psychosocial factors, such as support, depression, coping, and optimism are associated with pain, function, and satisfaction two years after total knee arthroplasty, shows a study from MD Anderson Cancer Center.