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Lupus

Link Between Diet and Lupus Flares: Epigenetics

Sunlight and smoking can cause oxidative stress. Oxidizing agents perturb T cell function in lupus patients by affecting DNA demethylation, which changes gene regulation. Is this how environmental factors trigger or worsen lupus? Listen to Bruce Richardson MD telling how he plans to find out.

Lupus

A rare vasculitis that is fatal in adolescence turns out to be caused by a mutation in interferon that affects the JAK pathway. This has implications for other auto-inflammatory diseases including lupus.

(AUDIO) Bruce Richardson MD describes strong evidence that environmental sources such as sunlight and diet alter DNA processing to affect immune cell function and influence the course of lupus.

David Pisetsky MD

(AUDIO) David Pisetsky MD, new President-elect of the US Bone and Joint Initiative, offers his perspective.on the role of rheumatologists in a patient-centered, multidisciplinary medical future.

Another case report describes coronary aneurysms in a lupus patient. These were discovered serendipitously, and she recovered after aggressive treatment.

(EULAR 2014) Based on physician's opinions and on some clinical indicators, the BAFF inhibitor belimumab is achieving impressive results against lupus in both the US and Germany.

Plenty for rheumatologists in NEJM this week: A deadly vasculitis, Phase 2 results for a new psoriatic arthritis drug, and a solution for constipation with opioids.

(EULAR 2014) Patients at a Toronto lupus clinic stopped immunosuppressants most successfully when they waited for serology to be negative and then tapered slowly.

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