Inflammation may underlie the link between major depressive disorder and RA.
References1. Vallerand IA, Lewinson RT, Frolkis AD, et al. Depression as a risk factor for the development of rheumatoid arthritis: a population-based cohort study. RMD Open. 2018;4:e000670. doi: 10.1136/rmdopen-2018-000670.2. Lewinson RT, Vallerand IA, Lowerison MW, et al. Depression is associated with an increased risk of psoriatic arthritis among patients with psoriasis: a population-based study. J Invest Dermatol. 2017;137:828-835.
Vallerand and fellow researchers at the University of Calgary in Alberta, Canada, found that major depressive disorder (MDD) significantly increases the risk of developing rheumatoid arthritis (RA).1 Scroll through the slides for the details of the study and the take-home points for clinicians.
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MDD, major depressive disorder; RA, rheumatoid arthritis; TNFÎ±, tumor necrosis factor alpha.
Note that depression may increase the risk of psoriatic arthritis.2
MDD, major depressive disorder; RA, rheumatoid arthritis; THIN, The Health Improvement Network.
Cases of MDD that developed after a diagnosis of RA were excluded from the study.
CI, confidence interval; HR, hazard ratio; MDD, major depressive disorder; RA, rheumatoid arthritis.
Patients in the MDD cohort were older, more likely to be female and to be current smokers, and more likely to have at least one comorbid disease and to use antidepressants.
In addition, patients in the MDD cohort developed RA at an earlier age compared with those in the general population cohort.