Does Early Onset of Sjögren Portend Worse Outcomes?

January 22, 2019

French researchers identified a specific phenotype along with predictive factors.

Anquetil and colleagues in France found that early-onset primary SjÃ¶gren syndrome is associated with a specific phenotype along with predictive factors.¹ Scroll through the slides for the details of the study and the take-home points for clinicians.

EULAR, European League Against Rheumatism.

ESSDAI, EULAR SjÃ¶gren’s Syndrome Disease Activity Index; EULAR, European League Against Rheumatism.

ESSDAI, EULAR SjÃ¶gren’s Syndrome Disease Activity Index; RF, rheumatoid factor.

Patients with early-onset disease were more likely to have salivary gland enlargement (P = .045), adenopathy (P = .006), purpura (P = .002), renal involvement (P = .003), hypergammaglobulinemia (P < .001), RF positivity (P < .001), low C3 level (P = .032), low C4 level (P = .048), and autoantibodies (anti-SSA, P < .001) (anti-SSB, P < .001).

ESSDAI, EULAR SjÃ¶gren’s Syndrome Disease Activity Index.

Reference1. Anquetil C, Hachulla E, Machuron F, et al. Is early-onset primary SjÃ¶gren’s syndrome a worse prognosis form of the disease?Rheumatology. 2018 Dec 17. doi: 10.1093/rheumatology/key392. [Epub ahead of print]

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Does Early Onset of Sjögren Portend Worse Outcomes?

Gregory M. Weiss, MD