
The EC approved upadacitinib for active polyarticular JIA in children 2 years and older, based on phase 1 SELECT-YOUTH efficacy and safety data.
Be aware that changes in geometry, bone mineral density, and micro-structure appear early in the disease course of axSpA.
Reference1. Neumann A, Haschka J, Kleyer A, et al. Cortical bone loss is an early feature of nonradiographic axial spondyloarthritis. Arthritis Res Ther. 2018;20:202. doi: 10.1186/s13075-018-1620-1.






