A Maternal Link to Osteoarthritis

May 6, 2019

OARSI 2019:  Men and women with a mother or sibling who have osteoarthritis, have an increased risk of osteoarthritis in the hips, knees and hands.

Men and women with a mother or sibling who have osteoarthritis, have an increased risk of osteoarthritis in the hips, knees and hands, researchers reported this weekend in Toronto at the Osteoarthritis Research Society International (OARSI) World Congress on Osteoarthritis.

The risk is higher in cases in which the mother or sibling has had osteoarthritis of the knee or hip so severe, that it required surgery.

“Our findings suggest a stronger role of genetic inheritance from the mother than the father in OA disease etiology, which has not been previously observed in OA research,” wrote researchers who were led by Eirik Weldingh, M.D., University of Oslo. Specifically, clinical and surgical hip osteoarthritis occurred in 16 and 10 percent of patients, respectively, and in 18 and 8 percent, respectively, of the knee. The increased relative risk of surgical hip and knee osteoarthritis was 1.58-1.92. Having a father with osteoarthritis did not increase the risk of osteoarthritis.