How exposure to vapor, gas, dust, and fumes can contribute to the progression of RA.
Reference1. Murphy D, Bellis K, Hutchinson D. Vapour, gas, dust and fume occupational exposures in male patients with rheumatoid arthritis resident in Cornwall (UK) and their association with rheumatoid factor and anti-cyclic protein antibodies: a retrospective clinical study. BMJ Open. 2018;8:e021754. doi: 10.1136/bmjopen-2018-021754.
Murphy and colleagues at Royal Cornwall Hospital and University of Exeter Medical School in Truro, Cornwall, UK, have discovered a link between vapor, gas, dust, and fumes inhaled as occupational exposures and increases in rheumatoid factor.1
Scroll through the slides for the details of the study and the take-home points for clinicians.
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ACPA, anti-citrullinated protein antibody; RF, rheumatoid factor; VGDF, vapor, gas, dust, and fume.
*Never smoker/no VGDF exposure, RF 24 vs never smoker/VGDF exposure, RF 36 (P = 0.03); never smoker/no VGDF exposure, RF 24 vs never smoker/≥2 VGDF exposures, RF 57 (P = 0.02); smoker/no VGDF exposure, RF 71 vs smoker/VGDF exposure, RF 95 (P = 0.04); and smoker/no VGDF exposure, RF 71 vs smoker/≥2 VGDF exposures, RF 113 (P = 0.01).
Further analysis by multivariate linear regression on the effect of pack-years smoked and cumulative VGDF exposures on RF levels demonstrated significance (R2 < 0.03; P < 0.0001).
A value of RF < 14 IU/mL was considered negative.